Nuclear Magnetic Resonance & Reaction Mechanism

The Nuclear Magnetic Resonance Spectroscopy Facility at the School of Chemistry is home to The Scottish High Field NMR Centre, housing a liquid/solid-state 800 MHz NMR spectrometer, the highest field available in Scotland. The facility is also equipped with a wide range of highly sensitive specialised NMR spectrometers, with expertise in analysis of a diverse range of systems – from small molecules to biomacromolecules and complex mixtures.

Why choose the University of Edinburgh School of Chemistry as a partner for your NMR needs?

  • Use the fully automated 800 MHz NMR spectrometer, offering the highest resolution and sensitivity in Scotland, as well as a suite of automated 600 – 400 MHz spectrometers supporting wide range of NMR experiments for small and large molecules.
  • High throughput service underpinned by cryoprobe technology – increased service speed and sensitivity providing cheaper solution to your problems.
  • Spectrometers operate with sub-milligram quantities of samples.
  • Unique reaction mechanism analysis equipment that enables monitoring of fast reactions in situ.
  • Come and use the facility yourself – after brief training, you can use it on a drop in basis, saving time and organization.

We Can Answer Your Questions

“What’s the structural composition of this?”
“What’s happening as this reaction takes place?”
Discuss your project with our highly skilled NMR staff, who can customize techniques and ways of acquiring NMR spectra and design experiments according to your needs.
NMR instruments in Lab

SERVICES AVAILABLE

  • Small Molecule Structure Determination including organic molecules and inorganic complexes using multinuclear NMR

  • Complex Mixture Analysis using 1H NMR spectroscopy of complex matrices including biofluids, foods, beverages or environmental samples. Chemical profiling, multivariate and quantitative analyses

  • Biomolecular NMR Spectrometry including:

    • acquisition of 3D triple-resonance experiments of isotopically labelled proteins for structure determination

    • ligand screening, both macromolecule and ligand-focused

  • Advanced Characterisation of:

    • low concentration small molecules on the microgram scale

    • reaction monitoring and elucidation of reaction mechanisms

  • Characterisation of solid powders including polymers, inorganic complexes and environmental samples.

 

EQUIPMENT AVAILABLE

  • 600 MHz Bruker AVANCE IIID 4-channel instrument with a quadruple-resonance 1H, 19F, 13C, 15N, QCI-F helium CryoProbe maximising sensitivity of 1 H and 19F, enabling multi-resonance experiments from −40 to +150 C

  • 500 MHz Bruker AVANCE NEO with a BBO H/F CryoProbe maximising sensitivity of X nuclei detection, from −40 to +150 C

  • 500 MHz Bruker AVANCE IIID with a BBO H/F CryoProbe Prodigy probe for fast acquisition of nuclei from 15N to 31P

  • 400 MHz Bruker AVANCE NEO 2-channel console with BBO room temperature probe: −150 to +150 C

  • 400 MHz Bruker Neo dual-purpose solid/liquid-state NMR spectrometer equipped with either a 4 mm solid-state CPMAS probe or a 5 mm liquid-state BBFO probe for acquisition of 1H, 19F and X nuclei (109Ag to 31P) spectra at temperatures ranging from -100 to +150 C.

  • 800 MHz Bruker Neo dual-purpose solid/liquid-state NMR spectrometer equipped with either a 5 mm liquid-state triple-resonance 1H/13C/15N TCI cryoprobe, maximising sensitivity for low concentration and biological samples, or a range of solid-state probes (1.3 to 3.2 mm diameter) for high resolution analysis of powders

  • Bruker InsightMR flow probe for online NMR reaction monitoring.

  • Stopped-flow NMR instrumentation for NMR monitoring of reactions on the millisecond to second timescale.

For more information please contact Dr Andrew Hall

Scientist at NMR Machine

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