Research in the Ingleson Group studies the fundamental and applied properties of boron compounds and other main group electrophiles (e.g. Zn, Al, P).
These are then utilized in our target transformations:
Inexpensive boron electrophiles are effective for the C-H borylation of (hetero)arenes. Borylation proceeds with high yield, good functional group tolerance and with excellent regioselectivity (controlled by electronic effects, or by directing groups). The borylated arene products can be esterified to provide boron derivatives more familiar to the synthetic community and more robust to protodeboronation (e.g. pinacol boronate esters).
For a representative recent publication see: Angew. Chem. Int. Ed. 2022, ASAP
This research endeavor focuses on using directed electrophilic borylation methods to incorporate boron into conjugated pi system to modulate key properties, particularly the frontier orbital energies and distribution.
For a representative publication see: Chem. Sci. 2022, 13, 1136.
This utilises borenium cations and neutral boranes to functionalize alkynes to form new vinyl boronates and new cyclic borylated compounds.
For representative publications see: Chem. Sci., 2020, 11, 3258.
We are also designing new Zn mediated "coupling reactions", particularly for C-H to C-B transformations.
For a representative publication in this area see: Chem. Sci. 2021, 12, 8190.
The group are also interested in developing new FLPs and other main group catalysts and new applications for main group catalysts.
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