Publications

A complete list of all the group's publications.

2024

194. Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution in In Situ 1D NMR Reaction Monitoring

Annabel Flook and Guy. C. Lloyd-Jones* 

J. Org. Chem., 89, 16586–16593, 2024

194. Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution in In Situ 1D NMR Reaction Monitoring

193. Kinetics and Mechanism of PPh3/Ni-Catalyzed, Zn-Mediated, Aryl Chloride Homocoupling: Antagonistic Effects of ZnCl2/Cl–

Nicole A. Fohn, Yuan Gao, Stephen Sproules, Gary S. Nichol, Colin M. Brennan, Alan J. Robinson, and Guy. C. Lloyd-Jones* 

J. Am. Chem. Soc., 146, 29913-29927, 2024

Kinetics and Mechanism of PPh3/Ni-Catalyzed, Zn-Mediated, Aryl Chloride Homocoupling: Antagonistic Effects of ZnCl2/Cl–

192. Kinetics of Sulfur-Transfer from Titanocene (Poly)Sulfides to Sulfenyl Chlorides: Rapid Metal-Assisted Concerted Substitution

Pedro H. Helou de Oliveira, Patrick J. Boaler, Guoxiong Hua, Nathan M. West, Robert T. Hembre, Jonathan M. Penney, Malik H. Al-Afyouni, J. Derek Woolins, Andrés García-Domínguez* and Guy C. Lloyd-Jones*

Chem. Sci., 15, 11875–11883, 2024 

Kinetics of Sulfur-Transfer from Titanocene (Poly)Sulfides to Sulfenyl Chlorides: Rapid Metal-Assisted Concerted Substitution

191. The Origins of High-Activity Cage-Catalyzed Michael Addition  

Patrick J. Boaler, Tomasz K. Piskorz, Laura E. Bickerton, Jianzhu Wang, Fernanda Duarte*, Guy. C. Lloyd-Jones* and Paul J. Lusby*

J. Am. Chem. Soc. 146, 19317–19326, 2024

The Origins of High-Activity Cage-Catalyzed Michael Addition

190. Mechanistic Basis of the Cu(OAc)2 Catalyzed Azide-Ynamine (3 + 2) Cycloaddition Reaction

Roderick P. Bunschoten, Frederik Peschke, Andrea Taladriz-Sender, Emma Alexander, Matthew J. Andrews, Alan R. Kennedy, Neal J. Fazakerley, Guy C. Lloyd Jones, Allan J.B. Watson* and Glenn A. Burley*

J. Am Chem. Soc., 146,13558–13570, 2024 

Mechanistic Basis of the Cu(OAc)2 Catalyzed Azide-Ynamine (3 + 2) Cycloaddition Reaction

189. A simple device for automated mixing of heterogeneous solid-liquid reactions during in-situ monitoring by NMR spectroscopy

Yuan Gao, Andrew M. R. Hall, Nicole A. Fohn, Edward J. King, Lloyd A. L. Mitchell, George A. Steedman, and Guy C. Lloyd-Jones*

Eur. J. Org. Chem., 20, e202400095, 2024

A simple device for automated mixing of heterogeneous solid-liquid reactions during in-situ monitoring by NMR spectroscopy

188. Speciation and kinetics of fluoride transfer from tetra-n-butylammonium difluorotriphenylsilicate (‘TBAT’)

Maciej M. Kucharski, Allan J. B. Watson, and Guy C. Lloyd-Jones*

Chem. Sci., 15, 4331–4340, 2024

Speciation and kinetics of fluoride transfer from tetra-n-butylammonium difluorotriphenylsilicate (‘TBAT’)

2023

187. Exogenous On and Off-cycle Cage Catalysis derived from Photo-Activating Host-Guest Encapsulation

Rebecca L. Spicer, Helen M. O’Connor, Yael Ben-Tal, Hang Zhou, Patrick J. Boaler, Fraser C. Milne, Euan K. Brechin,* Guy. C. Lloyd-Jones* and Paul J. Lusby*

Chem. Sci, 14, 14140–14145, 2023

Exogenous On and Off-cycle Cage Catalysis derived from Photo-Activating Host-Guest Encapsulation

186. TMSCF3-Mediated Conversion of Salicylates into alpha,alpha-Difluoro-3-Coumaranones: Chain Kinetics, Anion-Speciation, and Mechanism

Hannah B. Minshull and Guy C. Lloyd-Jones*

J. Org. Chem. 88, 17450–17460, 2023

TMSCF3-Mediated Conversion of Salicylates into alpha,alpha-Difluoro-3-Coumaranones: Chain Kinetics, Anion-Speciation, and Mechanism

185. Kinetics and Mechanism of Azole n−π*-Catalyzed Amine Acylation

Harvey J. A. Dale,  George, R. Hodges, and Guy C. Lloyd-Jones*

J. Am. Chem. Soc. 145, 18126–18140, 2023

Kinetics and Mechanism of Azole n−π*-Catalyzed Amine Acylation

184. Thiol Chlorination with N-Chlorosuccinimide: HCl-Catalyzed Release of Molecular Chlorine and the Dichotomous Effects of Water

Andrés García-Domínguez*, Nathan M. West, Robert T. Hembre and Guy C. Lloyd-Jones

ACS Catal., 13, 9487–9494, 2023

Thiol Chlorination with N-Chlorosuccinimide: HCl-Catalyzed Release of Molecular Chlorine and the Dichotomous Effects of Water

183. SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy

George Peat, Patrick J. Boaler, Claire L. Dickson, Guy C. Lloyd-Jones, and Dušan Uhrín*

Nat Commun, 14, 4410, 2023 

SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy

182. Direct Observation of Palladium Leaching from Pd/C by a Simple Method: X‐ray Absorption Spectroscopy of Heterogeneous Mixtures

Kenichi Uno, Takanori Itoh, Hidenori Sato, Guy C. Lloyd-Jones, and Yuya Orito*

ACS Omega, 24, 21787–21792, 2023

Direct Observation of Palladium Leaching from Pd/C by a Simple Method: X‐ray Absorption Spectroscopy of Heterogeneous Mixtures

2022

181. Kinetics of a Ni/Ir Photo-Catalyzed Coupling of ArBr with RBr: Intermediacy of ArNiII(L)Br and Rate/Selectivity Factors

Yael Ben-Tal and Guy C. Lloyd-Jones*

J. Am. Chem. Soc., 144, 15372–15382, 2022

 Kinetics of a Ni/Ir Photo-Catalyzed Coupling of ArBr with RBr: Intermediacy of ArNiII(L)Br and Rate/Selectivity Factors

180. In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation and Dysfunction at the Carbanion–Ate Interface

Andrés García-Domínguez, Andrew G. Leach, and Guy C. Lloyd-Jones*

Acc. Chem. Res., 55, 1324–1336, 2022

 In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation and Dysfunction at the Carbanion–Ate Interface

179. Asymmetric Azidation under Hydrogen Bonding Phase- Transfer Catalysis: A Combined Experimental and Computational Study

Jimmy Wang, Matthew A. Horwitz, Alexander B. Dürr, Francesco Ibba, Gabriele Pupo, Yuan Gao, Paolo Ricci, Kirsten E. Christensen, Tejas P. Pathak, Timothy D. W. Claridge,* Guy C. Lloyd-Jones,* Robert S. Paton,* and Véronique Gouverneur*

J. Am. Chem. Soc., 144, 4572–4584, 2022

Asymmetric Azidation under Hydrogen Bonding Phase- Transfer Catalysis: A Combined Experimental and Computational Study

178. Mechanistic Analysis by NMR Spectroscopy: a Users Guide

Yael Ben-Tal, Patrick J. Boaler, Harvey J. A. Dale, Ruth E. Dooley, Nicole A. Fohn, Yuan Gao, Andrés García-Domínguez, Katie M. Grant, Andrew M. R. Hall, Hannah L. D. Hayes, Maciej M. Kucharski, Ran Wei, and Guy C. Lloyd-Jones*

Prog. Nucl. Magn. Reson. Spectrosc., 129, 28–106, 2022

 Mechanistic Analysis by NMR Spectroscopy: a Users Guide

177. Inverse Isotope Effects in Single-Crystal to Single-Crystal Reactivity and the Isolation of a Rhodium Cyclooctane σ-Alkane Complex

Laurence R. Doyle,* Martin R. Galpin, Samantha K. Furfari, Bengt E. Tegner, Antonio J. Martínez-Martínez, Adrian C. Whitwood, Scott A. Hicks, Guy C. Lloyd-Jones, Stuart A. Macgregor,* and Andrew S. Weller*

Organometallics, 41, 284–292, 2022

Inverse Isotope Effects in Single-Crystal to Single-Crystal Reactivity and the Isolation of a Rhodium Cyclooctane σ-Alkane Complex

176. A Lewis Base Nucleofugality Parameter, NFB, and its Application in an Analysis of MIDA-boronate Hydrolysis Kinetics

Nicholas P. Taylor, Jorge A. Gonzalez, Gary S. Nichol, Andrés García-Domínguez, Andrew G. Leach and Guy C. Lloyd-Jones*

J. Org. Chem., 87, 721–729, 2022

A Lewis Base Nucleofugality Parameter, NFB, and its Application in an Analysis of MIDA-boronate Hydrolysis Kinetics

2021

175. Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?

Harvey J. A. Dale, Andrew G. Leach and Guy C. Lloyd-Jones*

J. Am. Chem. Soc., 143, 21079–21099, 2021

Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?

174. Controlled Synthesis of Well-Defined Polyaminoboranes on Scale Using a Robust and Efficient Catalyst

Claire N. Brodie, Timothy M. Boyd, Lia Sotorrios, David E. Ryan, Eimear Magee, Steven Hubbard, James S. Town, Guy C. Lloyd-Jones, David M. Haddleton,* Stuart A. Macgregor,* and Andrew S. Weller*

J. Am. Chem. Soc., 143, 21010–21023, 2021

Controlled Synthesis of Well-Defined Polyaminoboranes on Scale Using a Robust and Efficient Catalyst

173. Glossary of Terms used in Physical Organic Chemistry

Charles Perrin,* Alessandro Bagno, Silivia Braslavsky, Pedro Fernandes, Guy Lloyd-Jones, Herbert Mayr, Joseph Murdoch, Murdoch, Leo Radom, Zvi Rappoport, Marie-Françoise Ruasse, Hans-Ulrich Siehl, Thomas Tidwell, Einar Uggerud, and Ian Williams

Pure Appl. Chem., 94, in press, 2021

IUPAC Recommendations 2022

Glossary of Terms used in Physical Organic Chemistry

172. Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Pre-hydrolytic Pathways and Self/Auto-Catalysis

Hannah L. D. Hayes, Ran Wei, Michele Assante, Katherine J. Geogheghan, Na Jin, Simone Tomasi, Gary Noonan, Andrew G. Leach and Guy C. Lloyd-Jones*

J. Am. Chem. Soc., 143, 14814–14826, 2021

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Pre-hydrolytic Pathways and Self/Auto-Catalysis

171. FLIPS – Rapid Estimation of T1 for Quantitative NMR

Ran Wei, Claire L. Dickson, Dušan Uhrín, and Guy C. Lloyd-Jones*

J. Org. Chem., 86, 9023–9029, 2021

FLIPS – Rapid Estimation of T1 for Quantitative NMR

170. Stopped-Flow 19F NMR Spectroscopic Analysis of a Protodeboronation Proceeding at the Sub-Second Time-Scale

Ran Wei, Andrew M. R. Hall, Richard Behrens, Mark S. Pritchard, Edward J. King, and Guy C. Lloyd-Jones*

Eur. J. Org. Chem., 17, 2331-2342, 2021

Stopped-Flow 19F NMR Spectroscopic Analysis of a Protodeboronation Proceeding at the Sub-Second Time-Scale

169. Mechanism of Anion-Catalyzed C-H Silylation using TMSCF3: Kinetically-Controlled CF3-anionoid Partitioning as a Key Parameter

Andrés García-Domínguez, Pedro H. Helou de Oliveira, Gilian T. Thomas, Arnau R. Sugranyes and Guy C. Lloyd-Jones*

ACS Catal., 11, 3017–3025, 2021

Mechanism of Anion-Catalyzed C-H Silylation using TMSCF3: Kinetically-Controlled CF3-anionoid Partitioning as a Key Parameter

168. Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes

Harvey J. A. Dale, Chris Nottingham, Carl Poree and Guy C. Lloyd-Jones*

J. Am. Chem. Soc., 143, 2097–2107, 2021

Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes

167. Mechanistic Investigation of Rh(I)-Catalysed Asymmetric Suzuki- Miyaura Coupling with Racemic Allyl Halides

Lucy van Dijk, Ruchuta Ardkhean, Mireia Sidera, Sedef Karabiyikoglu, Özlem Sari, Timothy D. W. Claridge,* Guy C. Lloyd-Jones,* Robert S. Paton* and Stephen P. Fletcher*

Nature Catal., 4, 284–292, 2021

Mechanistic Investigation of Rh(I)-Catalysed Asymmetric Suzuki- Miyaura Coupling with Racemic Allyl Halides

166. CO cleavage via InIII alkoxide intermediates: In situ 13C NMR analysis of the mechanism of an enantioselective in-mediated cyclopropanation reaction

Jennifer L. Slaughter and Guy C. Lloyd-Jones*

Tetrahedron, 78, 131786, 2021

CO cleavage via InIII alkoxide intermediates: In situ 13C NMR analysis of the mechanism of an enantioselective in-mediated cyclopropanation reaction

2020

165. Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions

Andrés García-Domínguez, Thomas H. West, Johann J. Primozic, Katie M. Grant, Craig P. Johnston, Grant G. Cumming, Andrew G. Leach and Guy C. Lloyd-Jones*

J. Am. Chem. Soc., 142, 14649–14663, 2020

Highlighted in JACS Spotlights "Mediating Reagents Bridge the Gap for CF2 Transfer"

Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions

164. Kinetic Analysis of Domino Catalysis: a Case Study on Gold-Catalyzed Arylation

Liam T Ball, Tom Corrie, Alex Cresswell, and Guy C. Lloyd-Jones

ACS Catal., 10, 10420–10426, 2020

Kinetic Analysis of Domino Catalysis: a Case Study on Gold-Catalyzed Arylation

163. Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)

Megan Greaves, Thomas O. Ronson, Guy C. Lloyd-Jones, Feliu Maseras, Stephen Sproules and David J. Nelson

ACS Catal., 10, 10717–10725, 2020

Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)

162. Amine-Borane Dehydropolymerization using Rh-based Pre-Catalysts: Resting State Chain-Control and Efficient Polymer Synthesis

David E. Ryan, Kori A. Andrea, James J. Race, Timothy M. Boyd, Guy C. Lloyd–Jones, and Andrew S. Weller*

ACS Catal., 10, 7443–7448, 2020

Amine-Borane Dehydropolymerization using Rh-based Pre-Catalysts: Resting State Chain-Control and Efficient Polymer Synthesis

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