Edinburgh Single-Molecule Biophysics Laboratory

Laboratory houses a range of single-molecule and super-resolution microscopes enabling the visualisation and characterisation of individual molecules with a high spatial resolution (down to 20 nanometres).

Why choose the University of Edinburgh School of Chemistry as a partner for your imaging needs?

We have both commercial and home-built systems, allowing the imaging of fluorescent molecules in the full visible spectrum in vitro, in live/fixed cells, and in tissue. These technologies are particularly useful for biomedical research, and we routinely characterise molecules in human biofluids and tissue.

Scientist in front of a laser

SERVICES AVAILABLE

  • We image molecules in a range of biological samples, and can provide custom detection and can offer custom detection and characterisation solutions.

  • We can also provide data analysis, interpretation, and visualisation using a range of software solutions analyses.

EQUIPMENT AVAILABLE

  • Single-molecule confocal microscope (“single-molecule flow-cytommetry”) equipped with 405/488/515/635 nm excitation. FRET measurements, Fluorescence Correlation Spectroscopy (FCS), single-molecule burst analysis

  • Home-built TIRF microscope built around a Nikon Ti2 equipped with 405/488/515/561/638 nm excitation. Live cell imaging chamber. Single-molecule detection and particle tracking, super-resolution microscopy (dSTORM/PALM/DNA-PAINT/LIVE-PAINT)

  • Oxford Nanoimager equipped with 405/488/561/635nm excitation

  • Fluorescence Lifetime Imaging Microscope (FLIM)

 

For more information contact SoC-Facilities@ei.ed.ac.uk 

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